Purity 99% O Toluidine Fungicide Intermediate 2-Methylaniline

MF CH3C6H4NH2 O-Toluidine With Fungicide Intermediate

ortho-Toluidine is primarily used in the dyes manufacture. ortho-Toluidine is highly toxic to humans when absorbed through the skin, inhaled as swallowed, or vapor. Acute (short-term) exposure of humans to ortho-toluidine affects the blood (i.e., methemoglobinemia), with clinical signs of central nervous system depression. The chronic (long-term) effects in workers exposed to ortho-toluidine include anorexia, skin lesions, weight loss, anemia, central nervous system depression, cyanosis, and methemoglobinemia. Animal studies indicate that chronic exposure trtho-toluidine causes effects on the spleen, urinary bladder, liver, and blood. Occupational exposure to dyestuffs (including ortho-toluidine) is associated with an increased risk of bladder cancer. 2-Methylaniline hydrochloride (the hydrochloride salt of ortho-toluidine) was carcinogenic in rats and mice. ortho-Toluidine has been classified by EPA as a Group B2, probable human carcinogen.

Acute Effects:

o-Toluidine is highly toxic to humans when absorbed through the skin, inhaled as vapor, or swallowed. O-Toluidine changes hemoglobin (which carries oxygen in the blood) to methemoglobin; methemoglobinemia results in a decreased supply of oxygen to peripheral tissues.

Tests involving acute oral exposure of rats, have shown o-toluidine to have moderate acute toxicity.

Chronic Effects (Noncancer):

The long-term effects experienced by workers exposed to o-toluidine include anemia, anorexia, weight loss, cyanosis, methemoglobinemia, skin lesions, and central nervous system depression including dizziness, headache, and confusion.

Effects on the spleen, liver, urinary bladder, and body weight were reported in rats chronically exposed to 2-methylaniline hydrochloride in their feed. Other animal studies indicate that chronic exposure to o-toluidine causes effects to the blood, including methemoglobinemia, reticulocytosis, and anemia.

EPA has not established a Reference Concentration (RfC) or Reference Dose (RfD) for o-toluidine.

Reproductive/Developmental Effects:

Limited information regarding the reproductive or developmental effects of inhaled or ingested o-toluidine was located. One Russian study reported an increased frequency of tumors in offspring of mice injected with o-toluidine during gestation.

Cancer Risk:

An increased risk of bladder cancer has been reported among workers exposed to dyestuffs and dyestuff intermediates (including o-toluidine). However, no population of workers exposed only to o-toluidine has been described. Occasional cases of bladder tumors have been reported in workers exposed primarily to o-toluidine.

2-Methylaniline hydrochloride (the hydrochloride salt of o-toluidine) was carcinogenic in both rats and mice. A National Cancer Institute (NCI) study, in which animals were exposed to 2-methylaniline hydrochloride in feed, reported increased incidences of sarcomas of the spleen and other organs in male and female rats; mesotheliomas of the abdominal cavity and scrotum and fibromas of subcutaneous tissue in male rats; transitional-cell carcinomas of the urinary bladder and fibroadenomas or adenomas of the mammary gland in female rats; hepatocellular or adenomas in female mice; and hemangiosarcomas at various sites in male mice. These tumors have also been reported in other studies in which animals were exposed to 2-methylaniline hydrochloride in their diet.

The International Agency for Research on Cancer (IARC) has stated that there is sufficient evidence for the carcinogenicity of 2-methylaniline hydrochloride in experimental animals.

EPA has classified o-toluidine as a Group B2, probable human car - c 1 inogen.

EPA has calculated an oral cancer slope factor of 0.24 (mg/kg/d) .