99% Ortho Toluidine Colorless / Light Yellow Liquid For Hair Dyes

Colorless Or Light Yellow Liquid O-Toluidine For Hair Dyes

O-Toluidine (CH3C6H4NH2) is a colorless to pale-yellow liquid. It is a toxic substance harmful to the eyes, skin, and when swallowed or inhaled. ortho-Toluidine can cause cancer. Workers may be harmed from exposure to o-toluidine. The level of exposure depends upon the dose, duration, and work being done.

O-Toluidine is used in many industries. It is used in some hair dyes, weed and pest killers, rubber, and in some laboratory processes. Some examples of workers at risk of being exposed to o-toluidine include the following:

1. Workers who are exposed to certain hair dyes

2. Factory workers involved in rubber manufacture

3. Employees who are exposed to cigarette smoke

4. Laboratory workers who stain tissues or analyze glucose

NIOSH recommends that employers use Hierarchy of Controls to prevent injuries. If you work in an industry that uses o-toluidine, please read chemical labels and the accompanying Safety Data Sheets for hazard information to learn more about controlling chemical workplace exposures.

Absorption distribution and excretion

O-Toluidine is absorbed through inhalation and dermal contact. Extensive absorption of o-toluidine from the gastrointestinal tract was observed. The main excretion pathway is through the urine where up to one-third of the administered compound was recovered unchanged. .

The metabolism of o-toluidine involves many competing activating and deactivating pathways, including N-acetylation, N-oxidation and N-hydroxylation, and ring oxidation. 4-Hydroxylation and N-acetylation of toluidine are the major metabolic pathways in rats. The primary metabolism of o-toluidine takes place in the endoplasmic reticulum. The postulated activated form (based on comparison with other aromatic amines), N-acetoxy-o-toluidine, is a reactive ester that forms electrophilic arylnitrenium ions that can bind to DNA. Other activation pathways (ring-oxidation pathways) for aromatic amines include peroxidase-catalyzed reactions that form reactive metabolites (quinone-imines formed from nonconjugated phenolic metabolites) in the bladder. These metabolites can produce reactive oxygen species, resulting in oxidative cellular damage and compensatory cell proliferation. Support for this mechanism comes from studies of oxidative DNA damage induced by o-toluidine metabolites in cultured human cells (HL-60), calf thymus DNA, and DNA fragments from key genes thought to be involved in carcinogenesis (the c-Ha-ras oncogene and the p53 tumor-suppressor gene). Also supporting this mechanism are observations of o-toluidine-induced DNA damage (strand breaks) in cultured human bladder cells and bladder cells from rats and mice exposed in vivo to o-toluidine.