CAS No. 98-86-2 Phenylethanone Liquid For Fragrance Perfumes

CAS No. 98-86-2 Acetophenone Liquid For Fragrance Perfumes

Acetophenone is a reagent used in the production of fragrances and resin polymers.This compound is a contaminant of emerging concern.

Degradation of the aromatic ketone acetophenone is initiated by its carboxylation to benzoylacetate catalyzed by acetophenone carboxylase (Apc) in a reaction dependent on the hydrolysis of two ATP to ADP and Pi. Apc is a large protein complex which dissociates during purification into a heterooctameric Apc(αα′βγ)2 core complex of 482 kDa and Apcε of 34 kDa. In this report, we present the X-ray structure of the Apc(αα′βγ)2 core complex from Aromatoleum aromaticum at ca. 3 Å resolution which reveals a unique modular architecture and serves as model of a new enzyme family. Apcβ contains a novel domain fold composed of two β-sheets in a barrel-like arrangement running into a bundle of eight short polyproline (type II)-like helical segments. Apcα and Apcα′ possess ATP binding modules of the ASKHA superfamily integrated into their multidomain structures and presumably operate as ATP-dependent kinases for acetophenone and bicarbonate, respectively. Mechanistic aspects of the novel carboxylation reaction requiring massive structural rearrangements are discussed and criteria for specifically annotating the family members Apc,  carboxylase and hydantoinase are defined.

Acute exposure of humans to acetophenone vapor may produce skin irritation and transient corneal injury. One study noted a decrease in light sensitivity in exposed humans.

Acute oral exposure has been observed to cause hypnotic or sedative effects, hematological effects, and a weakened pulse in humans.

Congestion of the lungs, kidneys, and liver were reported in rats acutely exposed to high levels of acetophenone via inhalation.

Tests involving acute exposure of rats, mice, and rabbits have demonstrated acetophenone to have moderateacute toxicity from oral or dermal exposure.