Clear Liquid Methyl Propiolate Thiol Derivatizing Agent CAS 922-67-8

EINECS No. 213-083-5 Methyl Propiolate With Colorless

Methyl propiolate was used in the synthesis of polysubstituted 3-arylaminoacrylate and tetrahydropyrimidin-2-one derivatives. It was also used as a thiol derivatizing agent for capillary electrophoresis.

Methyl propiolate undergoes Lewis acid catalyzed reactions with alkenes in high yield. Mono and 1,2-disubstituted alkenes give mainly cyclobutenes. 1,1-disubstituted, trisubstituted and tetrasubstituted alkenes give only one adducts. Use of ethylaluminum dichloride as catalyst allows the isolation of pure products from acid-sensttive alkenes. Functionalized alkenes containing nonbasic functional groups are suitable substrates. Alkenes containing more basic functional groups ae suitable if 2 equiv of catalyst is used.

Toxicological information

Information on toxicological effects Acute toxicity

No data available

Skin corrosion/irritation

No data available

Serious eye damage/eye irritation

No data available

Respiratory or skin sensitisation

No data available

Germ cell mutagenicity

No data available

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

Inhalation - May cause respiratory irritation.

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available