99% Acetophenone Liquid CAS 98-86-2 Pharmaceutical Raw Materials

Organic Chemical Raw Materials Acetophenone Liquid Wtih CAS No. 98-86-2

Acetophenone (C6H5COCH3), an organic compound used as an ingredient in perfumes and as a chemical intermediate in the manufacture of pharmaceuticals, resins, flavouring agents, and a form of tear gas. It also has been used as a drug to induce sleep.

Acetophenone is used for the synthesis of many pharmaceuticals.

A Mannich reaction with dimethylamine and formaldehyde gives β-dimethylaminopropiophenone. Using diethylamine instead gives the diethylamino analog.

Acetophenone is currently listed as a Group D carcinogen indicating that there is no evidence at present that it causes cancer in humans.

No information is available on the chronic effects of acetophenone in humans. Degeneration of olfactory bulb cells was reported in rats chronically exposed via inhalation. In another study, chronic inhalation exposure of rats produced hematological effects and, at high doses, congestion of cardiac vessels and pronounced dystrophy of the liver.

In two studies, no effects were observed in rats chronically exposed to acetophenone in their diet. (2,3,5) EPA has not established a Reference Concentration (RfC) for acetophenone.

The Reference Dose (RfD) for acetophenone is 0.1 milligram per kilogram body weight per day (mg/kg/d) based on general toxicity in rats. The RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily oral exposure to the human population (including sensitive subgroups) that is likely to be without appreciable risk of deleterious noncancer effects during a lifetime. It is not a direct estimator of risk but rather a reference point to gauge the potential effects. At exposures increasingly greater than the RfD, the potential for adverse health effects increases. Lifetime exposure above the RfD does not imply that an adverse health effect would necessarily occur.