99% Dinotefuran Systemic Pesticide 165252-70-0 Pharma Intermediates

CAS NO. 165252-70-0 Fine Chemical Intermediates With Dinotefuran

Dinotefuran belongs to the neonicotinoid insecticides, as do imidacloprid and thiamethoxam. These compounds share a common mode of action. They are agonist of the nicotinic acetylcholine receptor, affecting the synapses in the central nervous system. These insecticides are gaining widespread use for controlling insect pests of agricultural importance (Elbert et al. 1998). They are insecticides with stomach, contact and systemic action, with relatively low toxicity to mammals and nontarget organisms. Discovered in 1998, dinotefuran [MTI-446, 1-methyl-2-nitro-3-(tetra-hydro-3-furylmethyl) guanidine] is one of the most recent neonicotinoids under development by Mitsui Chemicals (Tokyo, Japan). It has an especially high insecticidal activity against a broad range of hemipterous insects and a low mammalian toxicity (oral acute LD50 for rates between 2,000 and 2,800 and skin and eye acute percutaneous LD50 for rates >2,000 mg/kg; Tomlin 2000). Compared with other neonicotinoids, dinotefuran has been shown to be one of the most effective compounds against the adult male cockroach Periplaneta americana L.

Dinotefuran acts through contact and ingestion and results in the cessation of feeding within several hours of contact and death shortly after. Dinotefuran does not inhibit cholinesterase or interfere with sodium channels. Therefore, its mode of action is different from those of organophosphate, carbamate, and pyrethroid compounds. It appears that Dinotefuran acts as an agonist of insect nicotinic acetylcholine receptors, but it is postulated that Dinotefuran affects the nicotinic acetylcholine binding in a mode that differs from other neonicotinoid insecticides. It is reported that Dinotefuran was highly active on a certain silverleaf whitefly strain which developed resistance against imidacloprid.