165252-70-0 Dinotefuran Powder Raw Material Api For Controlling Insect Pests

Pharmaceutical Raw Materials Dinotefuran Powder With CAS NO. 165252-70-0

Dinotefuran belongs to the neonicotinoid insecticides, as do imidacloprid and thiamethoxam. These compounds share a common mode of action. They are agonist of the nicotinic acetylcholine receptor, affecting the synapses in the central nervous system. These insecticides are gaining widespread use for controlling insect pests of agricultural importance (Elbert et al. 1998). They are insecticides with stomach, contact and systemic action, with relatively low toxicity to mammals and nontarget organisms. Discovered in 1998, dinotefuran [MTI-446, 1-methyl-2-nitro-3-(tetra-hydro-3-furylmethyl) guanidine] is one of the most recent neonicotinoids under development by Mitsui Chemicals (Tokyo, Japan). It has an especially high insecticidal activity against a broad range of hemipterous insects and a low mammalian toxicity (oral acute LD50 for rates between 2,000 and 2,800 and skin and eye acute percutaneous LD50 for rates >2,000 mg/kg; Tomlin 2000). Compared with other neonicotinoids, dinotefuran has been shown to be one of the most effective compounds against the adult male cockroach Periplaneta americana L.

Dinotefuran is a neonicotinoid which is a chemical designed to mimic the effects of nicotine, found commonly in tobacco. Dinotefuran is also systemic, meaning that it is absorbed into the plants that it is applied on and moves through the entire plant body down to the root. Dinotefuran's mode of action is achieved by disrupting stimuli transmission within the nervous system of the targeted insect when the insect either ingests or absorbs the active into its body.

Dinotefuran blocks certain neuronal pathways that are much more common in insects than mammals. That is why the chemical is much more toxic to insects than humans or animals. As a result of this blockage, the insect begins to overproduce acetylcholine, an important neurotransmitter, resulting in the insect's paralysis, and eventually their death.