BOSI CAS NO. 123-39-7 N Methylformamide For Pharmaceutical Intermediates

CAS NO. 123-39-7 N Methylformamide Of Pharmaceutical Intermediates

N-methylformamide pure product is colorless transparent viscous liquid, m.p.-3.8℃, b.p.198℃, n25D 1.4310, relative density 0.9986(25℃), soluble in water, can also dissolve inorganic salts, has hygroscopic property, easily decomposed in acidic or alkaline solution. It can be synthesized by methyl formate, ethyl formate and other routes. It is an important organic synthesis solvent and intermediate, used in the synthesis of monamidine, bicamidine and other pesticide insecticides, medicine, synthetic leather, artificial leather, etc. And used as chemical fiber textile solvent. The substance is toxic, flammable and irritating.

Chemical properties:

Two salts can be formed by interaction with hydrogen chloride; HCONHCH3·HCl was formed in a non-polar solvent. (HCONHCH3)2·HCl is formed in the absence of solvent. It has little interaction with sodium metal at room temperature. Hydrolysis occurs in response to an acid or base. The acid hydrolysis rate is formamide > n-methylformamide >N, n-dimethylformamide. The rate of alkaline hydrolysis is formamide-n-methylformamide >N, n-dimethylformamide.

Operational disposal and storage:

Precautions for operation: airtight operation, comprehensive ventilation. Operators must be specially trained and strictly follow the operating procedures. It is recommended that operators wear a self-priming filter gas mask (half mask), chemical safety protective glasses, respirator permeation work clothes, and rubber gloves. Keep away from fire and heat. No smoking in the workplace. Use explosion-proof ventilation systems and equipment. Prevent leakage of vapors into the workplace air. Avoid contact with oxidants, acids and alkalis. Charge to control the flow rate to prevent static accumulation. Handling should be light, to prevent damage to the packaging and containers. Equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. Empty containers may retain harmful substances.

Storage precautions:

Store in a cool, ventilated warehouse. Keep away from fire and heat source. The temperature should not exceed 30℃. Should be stored separately from oxidants, acids and alkalis, do not mix storage. Explosion-proof lighting and ventilation facilities are adopted. Do not use mechanical equipment and tools that are prone to spark. The storage area shall be equipped with leakage emergency treatment equipment and appropriate holding materials.