NMF N Methylformamide 123-39-7 Raw Materials Of Chemical Industry

Organic Chemical Raw Material N-Methylformamide For Pharmaceutical Intermediates

We report FTIR studies of the 193 nm photodecomposition of N-methylformamide (NMF) isolated in solid parahydrogen (pH2) matrices at 1.9 K. By studying the detailed photokinetics we can distinguish between primary and secondary photoproducts. We observe single exponential decay of the NMF precursor upon irradiation and identify three competing primary dissociation channels: HCO + NHCH3; H + CONHCH3; and CO + CH3NH2 with branching ratios of 0.46(7):0.032(8):0.51(6), respectively. Two of the primary photoproducts (NHCH3 and CONHCH3) are observed for the first time using IR spectroscopy and assigned via ab initio calculations of the vibrational frequencies and intensities of these radicals. The dominant radical formation channel HCO + NHCH3 is consistent with efficient C–N peptide bond fission at this wavelength and escape of the nascent radical pair from the pH2 solvent cage. The significant branching 0.51(6) measured for the molecular channel CO + CH3NH2 is unexpected and raises important questions about the details of the in situ photochemistry. Starting from the NMF precursor, we observe and characterize spectroscopically a wide variety of secondary photoproducts including CH2NH, HCN, HNC, HNCO, CH3NCO, CH4, and NH3.

SYMPTOMS: Symptoms of exposure to this compound include irritation of the mucous membranes and upper respiratory tract. Other symptoms include liver damage, eye irritation with discomfort, tearing or blurring of vision, skin irritation with discomfort or rash, abnormalities of liver function with jaundice, temporary nervous system depression with anesthetic effects such as dizziness, headache, confusion, incoordination and loss of consciousness.

ACUTE/CHRONIC HAZARDS: N-Methylformamide may be absorbed through the skin and cause skin irritation. It may also irritate the eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992)

Moderately toxic by ingestion, intraperitoneal, intravenous, intramuscular, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. An eye irritant. A very dangerous fire hazard when exposed to heat or flame. Violent reaction with benzene sulfonyl chloride. When heated to decomposition it emits toxic fumes of NOx.