Chemical Intermediate Trifluoroacetic Acid C2HF3O2 With Purity 99%

Chemical Intermediate Trifluoroacetic Acid With Purity Over 99%

Trifluoroacetic acid (TFA), discovered at the early 20th century, has been widely used in organic synthesis as a solvent, catalyst and reagent. Many chemical transformations should be done with the aid of TFA, including rearrangements, functional group deprotections, oxidations, reductions, condensations, hydroarylations and trifluoromethylations. This review covers TFA synthetic applications, giving to the organic chemistry research community an opportunity to go in depth on the many diverse uses of this strong acid, water miscible and low boiling point reagent.

In the event of skin contact, the affected area should be flushed immediately with copious amounts of water. In case of eye contact, promptly wash with copious amounts of water for 15 min (lifting upper and lower lids occasionally). Medical attention should be obtained immediately in the event of contact with a large area of the skin or eye contact. If trifluoroacetic acid is ingested, obtain medical attention immediately. If large amounts of this compound are inhaled, move the person to fresh air and seek medical attention at once.

Carefully neutralize small spills of TFA with a suitable agent such as sodium carbonate, dilute with absorbent material, place in an appropriate container, and dispose of properly. Respiratory protection may be necessary in the event of a large spill or release in a confined area.