99% Trifluoroacetic Acid TFA Organic Chemistry Synthesis Reagents

Fine Chemicals Trifluoroacetic Acid For Various Purposes

Trifluoroacetic Acid is a corrosive organofluorine compound widely used to cleave N-BOC & t-butyl ester groups in peptide synthesis and as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength.

It can be a solvent for NMR spectroscopy and can act as a calibrant in mass spectrometry.

Trifluoroacetic Acid is used more commonly than sulfuric acid in synthesis because it is less oxidizing.

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TFA is the precursor to many other fluorinated compounds such as trifluoroacetic anhydride, trifluoroperacetic acid, and 2,2,2-trifluoroethanol. It is a reagent used in organic synthesis because of a combination of convenient properties: volatility, solubility in organic solvents, and its strength as an acid.TFA is also less oxidizing than sulfuric acid but more readily available in anhydrous form than many other acids. One complication to its use is that TFA forms an azeotrope with water (b. p. 105 °C).

TFA is popularly used as a strong acid to remove t-butyl derived side-chain protecting groups in Fmoc peptide synthesis, and in other organic syntheses to remove the t-butoxycarbonyl protecting group.

At a low concentration, TFA is used as an ion pairing agent in liquid chromatography (HPLC) of organic compounds, particularly peptides and small proteins. TFA is a versatile solvent for NMR spectroscopy (for materials stable in acid). It is also used as a calibrant in mass spectrometry.

TFA is used to produce trifluoroacetate salts.