Calibrant Pharma Intermediates CAS 76-05-1 TFA Acid Raw Materials

Pharmaceutical Raw Materials Trifluoroacetic Acid As A Calibrant

Trifluoroacetic acid (TFA) is an organofluorine compound with the chemical formula CF3CO2H. It is a structural analogue of acetic acid with all three of the acetyl group's hydrogen atoms replaced by fluorine atoms and is a colorless liquid with a vinegar-like odor.

TFA is popularly used as a strong acid to remove t-butyl derived side-chain protecting groups in Fmoc peptide synthesis, and in other organic syntheses to remove the t-butoxycarbonyl protecting group.

Trifluoroacetic acid (TFA), discovered at the early 20th century, has been widely used in organic synthesis as a solvent, catalyst and reagent. Many chemical transformations should be done with the aid of TFA, including rearrangements, functional group deprotections, oxidations, reductions, condensations, hydroarylations and trifluoromethylations. This review covers TFA synthetic applications, giving to the organic chemistry research community an opportunity to go in depth on the many diverse uses of this strong acid, water miscible and low boiling point reagent.

TFA is a naturally occurring substance but can also be produced by the breakdown of some HFCs or some HFOs and some HCFCs in the atmosphere.

TFA deposited on land and in water has the potential to accumulate in terminal water bodies (eg lakes) and in plants. However, based on the relative insensitivity of aquatic organisms to TFA, they are not expected to be impaired significantly. Its toxicity to algae, plants, fish, crustaceans animals and humans was found to be very low.

The Environmental effects assessment panel comprehensive summary of Trifluoroacetic acid (TFA) effects states that humans could be exposed to TFA via drinking water and food but there is no evidence to date of adverse effects on health. Recently the Federal Environment Agency UBA issued a revised guidance value for TFA in drinking water, based on improved toxicological studies availability for trifluoroacetate salts. This sets a drinking water health guidance value of 60 μg/L and a target value of 10 μg/L. The UBA was able to set a toxicologically justified LWTW for drinking water. The LWTW of 60 µg/L is based on the life-long tolerable daily intake of TFA via the drinking water (assumption: 2 L per day), in which no harm to human health is to be expected. This guideline replaces the health orientation value (GOW) of 3 µg/l (maximum values that apply if the toxicological data is incomplete). Relevant background information: From the 2021 EEAP scientific assessment, analysis of 1187 samples of rainwater collected in eight locations across Germany in 2018–2019 showed median and a precipitation-weighted mean concentration of TFA of 0.210 μg/L and 0.335 μg/L, respectively. The maximum measured concentration was 57 μg/L. The study on Future emissions and atmospheric fate of HFC-1234yf from mobile air conditioners in Europe assessed the future emissions of HFO-1234yf after a complete conversion of the European vehicle fleet and calculated that the use of HFO-1234yf would result in expected average values of 0.6 – 0.8 µg/L of TFA in European rainwater.